Details

Droperidol is a sedative, tranquilizer, and anti-nausea medicine. Droperidol is used to reduce nausea and vomiting caused by surgery or other medical procedures. To make sure droperidol is safe for you, tell your doctor if you have heart disease, congestive heart failure a heart rhythm disorder high blood pressure an electrolyte imbalance (such as low levels of potassium or magnesium in your blood) liver or kidney disease pheochromocytoma (tumour of the adrenal gland) or a history of alcohol abuse. Droperidol is given as an injection through a needle placed into a muscle or a vein.

Typical Uses

Dronedarone is used for treatment of irregular rhythm of heartbeats (paroxysmal or persistent atrial fibrillation or atrial flutter) and to prevent recurrence of the problem and hospitalization for irregular heartbeats (arrhythmias).

Side Effects

Some of the side effects of droperidol include headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats a light-headed feeling, like you might pass out numbness or tingly feeling confusion, hallucinations bronchospasm (wheezing, chest tightness, trouble breathing) twitching or uncontrollable movements of your eyes, tongue, jaw, or neck or severe nervous system reaction-very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors.

Drug Interactions

• Droperidol+abarelix- Using droperidol together with abarelix can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhoea or vomiting).

• Droperidol+amoxapine- Using droperidol together with amoxapine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhoea or vomiting).

• Droperidol+atomoxetine- Using droperidol together with atomoxetine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances.

• Droperidol+bosutinib- Using droperidol together with bosutinib can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be m

Mechanism of action

Droperidol produces marked tranquilization and sedation. It allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex alertness. Droperidol produces an antiemetic effect as evidenced by the antagonism of apomorphine in dogs. It lowers the incidence of nausea and vomiting during surgical procedures and provides antiemetic protection in the postoperative period. Droperidol potentiates other CNS depressants. It produces mild alpha-adrenergic blockade, peripheral vascular dilatation and reduction of the presser effect of epinephrine. It can produce hypotension and decreased peripheral vascular resistance and may decrease pulmonary arterial pressure (particularly if it is abnormally high). It may reduce the incidence of epinephrine-induced arrhythmias, but it does not prevent other cardiac arrhythmias.

Pregnancy Category : C