Details

Amoxapine inhibits the neuronal re-uptake of noradrenaline and serotonin (5-HT2) in the CNS. It also blocks the response of dopamine receptors to dopamine. Absorption: Readily absorbed from the GI tract (oral). Distribution: Enters breast milk. Protein-binding: Extensive. Metabolism: Undergoes hydroxylation converted to 8-hydroxyamoxapine and 7-hydroxyamoxapine. Excretion: Urine (as metabolites). Elimination half-life: 30 hr (8-hydroxyamoxapine), 6.5 hr (7-hydroxyamoxapine).