Details

Carbinoxamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Carbinoxamine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold. To make sure carbinoxamine is safe for you, tell your doctor if you have narrow-angle glaucoma a stomach ulcer a blockage in your digestive tract (stomach or intestines) heart disease or high blood pressure an enlarged prostate urination problems asthma or overactive thyroid.

Typical Uses

Carbinoxamine is used to temporarily relieve symptoms caused by the common cold, flu, allergies, or other breathing illnesses (such as sinusitis, bronchitis). Antihistamines help relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing. Decongestants help to relieve stuffy nose and ear congestion symptoms. Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor.

Side Effects

Stop using carbinoxamine and get immediate medical assistance if you have symptoms such as a light-headed feeling, like you might pass out urinating less than usual or not at all wheezing, tightness in your chest pounding heartbeats or fluttering in your chest easy bruising or bleeding or pale or yellowed skin, dark coloured urine, fever, confusion or weakness.

Drug Interactions

• Carbinoxamine+propoxyphene- Using propoxyphene together with carbinoxamine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should take propoxyphene exactly as prescribed by your doctor.

• Carbinoxamine+potassium citrate- The following interaction applies only if you are taking potassium in a solid formulation. Talk to your doctor before using potassium oral tablets or capsules together with carbinoxamine. Depending on the dose of carbinoxamine and your overall physical health, combining these medications may increase the irritant effects of potassium on your stomach and upper intestine.

• Carbinoxamine+topiramate- Topiramate can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like carbinoxamine. Heat stroke and hospitalization may occur in some people, especially in warm weather and during vigorous exercise. Children are particularly susceptible.

• Carbinoxamine+zonisamide- Zonisamide can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like carbinoxamine. Heat stroke and hospitalization may occur in some people, especially in warm weather and during vigorous exercise. Children are particularly susceptible.

Mechanism of action

Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.

Pregnancy Category : C