Details

Benserazide is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor, prescribed for Parkinson's syndrome.

Typical Uses

Benserazide is used in the treatment of Parkinson's syndrome. Take this medication by mouth exactly as prescribed. This is best taken with or just after meals. Because this medication has a bitter taste, swallow the capsules whole. Do not increase your dose or take this more often without your doctor's approval.

Side Effects

Contact your doctor if you develop involuntary or abnormal movements such as muscle twitching or blinking or have difficulty moving while taking this drug. Flushing, headache, hand tremor, stomach upset, dry mouth, hiccups, blurred vision, change in sexual desire, weight changes, sweating and moodiness may occur as your body adjusts to the medication.

Drug Interactions

Tell your doctor of any over-the-counter or prescription medication you may take including methyldopa, reserpine, drugs to treat schizophrenia, antidepressants, anti-anxiety drugs, phenytoin. Limit alcohol intake while taking this medication.

Mechanism of action

Benserazide is a precursor to the neurotransmitter dopamine which is administered to increase its levels in the central nervous system. However, most benserazide is decarboxylated to dopamine before it reaches the brain, and since dopamine is unable to cross the blood brain barrier, this translates to little therapeutic gain with strong peripheral side effects. Benserazide inhibits this decarboxylation, and since it itself cannot cross the blood brain barrier, this allows dopamine to build up solely in the brain instead.

Pregnancy Category : B