Details

Asenapine is an antipsychotic medication. It works by changing the actions of chemicals in the brain. Asenapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults. Asenapine can cause serious neurological problems. It is not approved for use in psychotic conditions related to dementia. Asenapine may increase the risk of death in older adults with dementia-related conditions. To make sure asenapine is safe for you, tell your doctor if you have liver disease, heart disease, high blood pressure, heart rhythm problems history of heart attack, stroke or breast cancer seizures or epilepsy diabetes (asenapine may raise your blood sugar) trouble swallowing Parkinson's disease and so on.

Typical Uses

Asenapine is used to treat certain mental/mood disorders (such as schizophrenia, bipolar disorder). Asenapine helps you to think more clearly, feel less nervous, and take part in everyday life. It may also help to decrease hallucinations (hearing/seeing things that are not there) and prevent severe mood swings. Asenapine is a psychiatric medication that belongs to the class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain (neurotransmitters). This medication may also be used in combination with other medication to treat depression.

Side Effects

Contact your doctor immediately if you show some side effects of asenapine such as very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs slow heart rate, feeling like you might pass out ulcers, blisters, swelling, or peeling of your gums after using the sublingual tablet sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance sudden ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing seizure (convulsions) or unusual thoughts or behaviour, hallucinations, or thoughts about hurting yourself.

Drug Interactions

• Asenapine+amiodarone- Using amiodarone together with asenapine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect.

• Asenapine+anagrelide- Using anagrelide together with asenapine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect.

• Asenapine+bupropion- Bupropion may rarely cause seizures, and combining it with other medications that can also cause seizures such as asenapine may increase that risk. The interaction may be more likely if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumour or head trauma.

• Asenapine+ceritinib- Using ceritinib together with asenapine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect.

• Asenapine+dolasetron- Using dolasetron together with asenapine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect.

Mechanism of action

Asenapine is an atypical antipsychotic agent, prescribed for schizophrenia and acute mania with bipolar disorder. It works by affecting the levels of chemicals called dopamine and serotonin (neurotransmitters) thereby restoring the balance of these chemicals in brain.

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