Details

Urofollitropin is a purified form of a hormone called follicle-stimulating hormone (FSH). This hormone is important in the development of follicles (eggs) that are produced by the ovaries in women. Urofollitropin is used together with other medicines to treat infertility in women with FSH deficiency. Urofollitropin is also used to help the ovaries produce multiple eggs for use in "in-vitro" fertilization. Urofollitropin alone will not cause ovulation (production of an egg by the ovaries). You will need to receive other medicines to stimulate ovulation. You should not use this medicine if you have primary ovarian failure, abnormal vaginal bleeding, uncontrolled thyroid or adrenal gland disorders, an ovarian cyst, breast cancer, uterine or ovarian cancer, a pituitary gland tumour, or infertility that is not caused by lack of ovulation. To make sure urofollitropin is safe for you, tell your doctor if you have asthma a history of stomach surgery a history of ovarian cyst or "torsion" (twisting) of your ovary or risk factors for blood clots (such as diabetes, smoking, heart disease, coronary artery disease,

Typical Uses

Urofollitropin is used to treat certain fertility problems in women. It provides the hormone (FSH) that helps cause the ovaries to produce eggs. This medication is usually used in combination with another hormone (hCG) for the growth and release of a mature egg (ovulation). This medication is not recommended for women whose ovaries no longer make eggs properly (primary ovarian failure).

Side Effects

Common side effects may include sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision balance chest pain, sudden cough, wheezing, rapid breathing, coughing up blood or pain, swelling, warmth, or redness in one or both legs stomach cramps or bloating headache, general pain nausea trouble breathing hot flashes or mild pelvic pain, pain after an egg is removed for in-vitro fertilization.

Drug Interactions

• Urofollitropin+ganirelix- Using ganirelix together with urofollitropin may decrease the effects of urofollitropin. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs.

Mechanism of action

FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signalling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.

Pregnancy Category : X