Details

Progesterone is a female hormone important for the regulation of ovulation and menstruation. Progesterone is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body. It is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving oestrogen hormone replacement therapy. Progesterone should not be used to prevent heart disease or dementia, because this medicine may actually increase your risk of developing these conditions. You should not use progesterone if you are allergic to it, or if you have abnormal vaginal bleeding that a doctor has not checked a history of breast cancer liver disease a peanut allergy if you are pregnant if you have had a stroke, heart attack, or blood clot within the past year or if you have recently had an incomplete miscarriage or "missed" abortion. Using progesterone can increase your risk of blood clots, stroke, heart attack, or breast cancer. Progesterone should not be used in pregnancy.

Typical Uses

Progesterone is used to treat overgrowth of the lining of the uterus. It's also prescribed to treat amenorrhea (a lack of menstrual periods) caused by stress, birth control, or other circumstances. As a medication, progesterone is used in hormone replacement therapy (HRT) to increase or replace levels of progesterone that your body may not have or make enough of to carry out certain bodily functions. Progesterone is also a naturally occurring hormone that women produce in their ovaries.

Side Effects

Common progesterone side effects may include unusual vaginal bleeding pain or burning when you urinate a breast lump sudden vision problems, severe headache or pain behind your eyes symptoms of depression (sleep problems, weakness, mood changes) severe dizziness or drowsiness, spinning sensation, confusion, shortness of breath heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes) signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with speech or balance signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood or signs of a blood clot in your leg - pain, swelling, warmth, or redness in one or both legs.

Drug Interactions

• Progesterone+edoxaban- Progesterone may increase the blood levels of edoxaban. This can increase the risk of serious or life-threatening bleeding complications. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications.

Mechanism of action

Progesterone stimulates luteal actions, changes in uterus and vagina as seen in early pregnancy. It also has prolonged uterotrophic effect. Contractile response of the myometrium to oxytocin is inhibited.

Pregnancy Category : B