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Pheniramine is an antihistamine combination. It works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. Relieving symptoms of runny nose and sneezing due to colds, upper respiratory infections, and allergies. Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. It is sold under the brand name Avil by the pharmaceutical company Aventis. Neo Citran contains Pheniramine.