Details

Etodolac is a non-steroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Etodolac is used to treat mild to moderate pain, osteoarthritis, or rheumatoid arthritis. Etodolac can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Etodolac may also cause stomach or intestinal bleeding, which can be fatal. To make sure etodolac is safe for you, tell your doctor if you have heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke a history of heart attack, stroke, or blood clot a history of stomach ulcers or bleeding asthma liver or kidney disease or fluid retention. Taking etodolac in third trimester of pregnancy may harm the unborn baby. The etodolac regular tablet is not approved for use by anyone younger than 18 years old. The extended-release form of etodolac is not approved for use by anyone younger than 6 years old.

Typical Uses

Etodolac is used to relieve pain from various conditions. It also reduces pain, swelling, and joint stiffness from arthritis. This medication is known as a non-steroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This medication may also be used to treat gout attacks.

Side Effects

Seek immediate medical assistance if you have signs of a heart attack or stroke such as chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech or feeling short of breath. Stop using etodolac and inform your doctor if you have changes in your vision the first sign of any skin rash, no matter how mild shortness of breath (even with mild exertion) swelling or rapid weight gain signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds liver problems - nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes) kidney problems - little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath low red blood cells (anaemia) - pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating or severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Drug Interactions

• Etodolac+adefovir- Talk to your doctor before using adefovir together with etodolac. Adefovir may cause kidney problems, and combining it with other medications that can also affect the kidney such as etodolac may increase that risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.

• Etodolac+apixaban- Using apixaban together with etodolac may increase the risk of bleeding, including severe and sometimes fatal haemorrhage. Talk to your doctor if you have any questions or concerns.

• Etodolac+cabozantinib- Using cabozantinib together with etodolac may increase the risk of bleeding. In clinical studies, treatment with cabozantinib alone has been associated with severe and sometimes fatal haemorrhage. Talk to your doctor if you have any questions or concerns.

• Etodolac+cidofovir- Using cidofovir together with etodolac is not recommended. Cidofovir may cause kidney damage, and combining it with other medications that can also affect the kidney such as etodolac may increase that risk. If you have been receiving etodolac, you may need to wait at least seven days after your last dose before you can start treatment with cidofovir.

• Etodolac+leflunomide- Leflunomide may cause liver damage and taking it with other medications that can also affect the liver such as etodolac may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications.

Mechanism of action

Etodolac belongs to a class of medicine called non-steroidal anti-inflammatory drugs (NSAIDs). Etodolac exerts a lasting analgesic and an anti-inflammatory effect as it reduces the production of pain stimulating chemicals (prostaglandins) by inhibiting the enzyme cyclooxygenase (COX).

Pregnancy Category : C