Details

Dinoprostone is a prostaglandin, a hormone-like substance that is naturally produced by tissues in the body. Dinoprostone topical is used in a pregnant woman to relax the muscles of the cervix (opening of the uterus) in preparation for inducing labour at the end of a pregnancy. You should not be treated with this medication if you are allergic to prostaglandins, or if you have active genital herpes with a vaginal lesion placenta previa (the placenta is below the foetus in your uterus) or if your water has broken. To make sure you can safely use dinoprostone topical tell your doctor if you have kidney disease liver disease glaucoma a history of asthma if you are 30 years or older or if your pregnancy is at full term (40 weeks).

Typical Uses

Dinoprostone is used to help prepare your cervix (the lower opening of the womb) for labour and delivery. It is used in women who are having a normal pregnancy and who are at or near their delivery due date. Dinoprostone is a natural substance that your body makes in preparation for labour. It relaxes and softens your cervix (cervical ripening) to allow the baby to pass through the birth canal during delivery.

Side Effects

Some of the side effects of dinoprostone include fever sudden vaginal bleeding cough, wheezing, chest tightness, trouble breathing or pale skin, blue coloured lips. Post birth of your baby, tell your doctor if you experience weakness or fainting unusual bleeding from your nose, mouth, vagina, or rectum bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds sudden numbness or weakness, especially on one side of the body sudden severe headache, confusion, problems with vision, speech, or balance unusual bruising, purple or red pinpoint spots under your skin bleeding from a wound, surgical incision, or vein where an IV was placed any bleeding that will not stop.

Drug Interactions

• Dinoprostone+ergonovine- Using dinoprostone topical and ergonovine is not recommended. Taking these drugs together can cause symptoms of severe cramping or bleeding.

• Dinoprostone+mifepristone- Using dinoprostone topical and mifepristone is not recommended. Taking these drugs together can cause symptoms of severe cramping or bleeding.

• Dinoprostone+oxytocin- Using oxytocin together with dinoprostone topical can increase your response to oxytocin and increase your risk of additional uterine problems or lead to uterine rupture. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications.

• Dinoprostone+misoprostol- Using dinoprostone topical and misoprostol is not recommended. Taking these drugs together can cause symptoms of severe cramping or bleeding.

Mechanism of action

Dinoprostone is a naturally occurring substance called prostaglandin. It softens and opens the part of the birth canal known as the cervix thereby inducing the labour.

Pregnancy Category : C