Details

Danazol is a man-made form of a steroid. Danazol affects the ovaries and pituitary gland and prevents the release of certain hormones in the body. Danazol is used to treat endometriosis and fibrocystic breast disease. Danazol is also used to prevent attacks of angioedema in people with an inherited form of this disorder (hereditary angioedema). To make sure you can safely take danazol, tell your doctor if you have heart disease, high blood pressure, coronary artery disease, congestive heart failure high cholesterol or triglycerides a history of breast cancer diabetes hypoparathyroidism, or low levels of calcium in your blood a seizure disorder kidney or liver disease or migraine headaches. Danazol can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use if you are pregnant.

Typical Uses

Danazol is used in women to treat pelvic pain and infertility due to a certain uterus disorder (endometriosis) and also to treat breast pain/tenderness/nodules due to a certain breast condition (fibrocystic breast disease). It is also used in both men and women to prevent swelling of the abdomen/arms/legs/face/airway due to a certain congenital disease (hereditary angioedema). Danazol is an androgen similar to testosterone. For the treatment of endometriosis and fibrocystic breast disease, it works by decreasing the amount of hormones made by the ovaries. These hormones usually make the conditions worse. For the treatment of angioedema, danazol helps to increase the amount of a certain protein in your body's defence system (immune system).

Side Effects

In rare cases, danazol can cause a condition which results in the breakdown of skeletal muscle tissue, leading to kidney failure. Inform your doctor immediately if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark coloured urine. Some of the other side effects of danazol include sudden numbness or weakness (especially on one side of the body), confusion, problems with speech or balance severe headache, ringing in your ears, dizziness, nausea, vomiting, vision problems, pain behind your eyes chest pain, sudden cough, wheezing, rapid breathing, coughing up blood pain, swelling, warmth, or redness in one or both legs swelling or rapid weight gain, especially in your face and midsection bloody, black, or tarry stools cough up blood or vomit that looks like coffee grounds or upper stomach pain, itching, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes).

Drug Interactions

• Danazol+atorvastatin- Talk to your doctor before using atorvastatin together with danazol. Combining these medications may significantly increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death.

• Danazol+anisindione- Using anisindione together with danazol may cause you to bleed more easily. You may need a dose adjustment based on your prothrombin time.

• Danazol+cerivastatin- Talk to your doctor before using cerivastatin together with danazol. Combining these medications may significantly increase the blood levels of cerivastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death.

• Danazol+halofantrine- Danazol may increase the blood levels of halofantrine. High blood levels of halofantrine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances.

• Danazol+mipomersen- Mipomersen may cause liver problems, and using it with other medications that can als

Mechanism of action

Danazol belongs to a group of medicines called antigonadotropins. It relieves the symptoms by altering the effects of certain hormones in the body.

Pregnancy Category : X