Details

Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin was discovered and developed by Beecham. It is sold under a number of trade names, including Cloxapen and Orbenin. Cloxacillin is used against staphylococci that produce beta-lactamase, due to its large R chain which doesn't allow the beta-lactamases to bind. This drug has a weaker antibacterial activity than benzylpenicillin, and is devoid of serious toxicity except for allergic reactions. It has been suggested, in one study, that increased use of cloxacillin may permit reduced use of vancomycin.