Details

Ciclesonide is a man-made steroid that prevents the release of substances in the body that cause inflammation. Ciclesonide nasal (for the nose) is used to treat nasal symptoms (congestion, sneezing, runny nose) caused by seasonal allergies in adults and children as young as 6 years old. Ciclesonide nasal is also used to treat nasal symptoms caused by year-round allergies in adults and children who are at least 12 years old. To make sure ciclesonide nasal is safe for you, tell your doctor if you have asthma, tuberculosis, or other lung problems any type of infection caused by bacteria, virus, fungus, or parasites glaucoma, cataracts, or herpes infection of the eyes a sore inside your nose that has not yet healed a recent nose injury or surgery or if you have recently used any other steroid medicine.

Typical Uses

Ciclesonide is used to prevent and reduce the symptoms (wheezing and shortness of breath) caused by asthma. This medication belongs to a class of drugs known as corticosteroids. It works by reducing the swelling of the airways in the lungs to make breathing easier. Ciclesonide must be taken regularly to be effective. It does not work right away and should not be used to relieve sudden asthma attacks. If an asthma attack occurs, use your quick-relief inhaler as prescribed.

Side Effects

Ciclesonide is a nasal steroid medicine which can be absorbed into your bloodstream, which may cause steroid side effects throughout the body. Tell your doctor if you have weight gain (especially in your face or your upper back and torso) slow wound healing, thinning skin, increased body hair irregular menstrual periods, changes in sexual function or muscle weakness, tired feeling, depression, anxiety, feeling irritable. Ciclesonide may also cause runny or bloody nose, crusting inside the nose, whistling sound when you breathe sores or white patches in or around your nostrils fever, chills, body aches, nausea, vomiting blurred vision, tunnel vision, eye pain, seeing halos around lights or signs of a hormonal disorder-worsening tiredness or weakness, feeling light-headed, vomiting, loss of appetite, diarrhoea, and weight loss.

Drug Interactions

• Ciclesonide+amprenavir- Talk to your doctor before using ciclesonide nasal together with amprenavir. Combining these medications may increase the absorption of ciclesonide nasal into the blood stream.

• Ciclesonide+boceprevir- Talk to your doctor before using ciclesonide nasal together with boceprevir. Combining these medications may increase the absorption of ciclesonide nasal into the blood stream.

• Ciclesonide+cobicistat- Talk to your doctor before using ciclesonide nasal together with cobicistat. Combining these medications may increase the absorption of ciclesonide nasal into the blood stream.

• Ciclesonide+darunavir- Talk to your doctor before using ciclesonide nasal together with darunavir. Combining these medications may increase the absorption of ciclesonide nasal into the blood stream.

• Ciclesonide+fosamprenavir- Talk to your doctor before using ciclesonide nasal together with fosamprenavir. Combining these medications may increase the absorption of ciclesonide nasal into the blood stream.

Mechanism of action

Ciclesonide reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorph nuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Ciclesonide is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.

Pregnancy Category : C