Details

Carboplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. Carboplatin is used together with other cancer medications to treat ovarian cancer. You should not receive carboplatin if you have severe bleeding or bone marrow suppression. Carboplatin can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. To make sure carboplatin is safe for you, tell your doctor if you have liver disease kidney disease a weak immune system or if you have received carboplatin in the past.

Typical Uses

Carboplatin is used to treat various types of cancer. It is a chemotherapy drug that contains platinum. It is used alone or in combination with other medications to slow or stop cancer cell growth. Carboplatin is usually given by infusion into a vein (intravenously-IV) over at least 15 minutes by a doctor. In general, courses of carboplatin treatment should not be given more often than once every 4 weeks.

Side Effects

Get immediate medical assistance if you experience symptoms such as pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin fever, chills, body aches, flu symptoms, sores in your mouth and throat severe or ongoing vomiting stomach pain, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes) numbness or tingly feeling in your hands or feet hearing or vision problems skin changes where the medicine was injected or low magnesium (confusion, uneven heart rate, jerking muscle movements, muscle weakness or limp feeling).

Drug Interactions

• Carboplatin+adalimumab- Using adalimumab together with carboplatin may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.

• Carboplatin+BCG- If you are currently being treated or have recently been treated with carboplatin, you should talk to your doctor before receiving BCG. Depending on the dose and length of time you have been on carboplatin, you may be at risk for developing an infection from the vaccine or have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of carboplatin therapy.

• Carboplatin+deferiprone- Deferiprone can lower white blood cell count, and combining it with other medications that can also affect bone marrow function such as carboplatin may increase the risk. You may be more likely to develop serious and potentially life-threatening infections as a result. You should seek immediate medical attention if you have signs and symptoms of infection such as fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.

• Carboplatin+golimumab- Using carboplatin together with golimumab may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.

Mechanism of action

Carboplatin belongs to a class of medication called antineoplastic or alkalyting agents. It is a platinum-containing compound. Carboplatin kills cancer cells by binding to cell’s DNA and interfering with the repair mechanism of the cell at all stages of the cell cycle, eventually leading to cell death. It thereby slows down or stops the growth of cancer cells in the body.

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