Details

Azatadine is an antihistamine. Azatadine blocks the effects of the naturally occurring chemical histamine in your body. Azatadine is used to treat sneezing runny nose itching, watery eyes hives rashes itching and other symptoms of allergies and the common cold. Alcohol may increase drowsiness and dizziness while you are taking azatadine. Before taking this medication, tell your doctor if you have glaucoma or increased pressure in the eye a stomach ulcer an enlarged prostate, bladder problems or difficulty urinating an overactive thyroid (hyperthyroidism) hypertension or any type of heart problems or asthma.

Typical Uses

Azatadine provides relief of symptoms of allergic reactions such as rash, hives, watery eyes, runny nose, itching eyes and sneezing. It may also be used to treat motion sickness, relief of anxiety or tension, or sleeplessness.

Side Effects

Azatadine may cause drowsiness, dizziness, headache, loss of appetite (less likely with cyproheptadine), stomach upset, vision changes, irritability, dry mouth and nose. These effects should subside as your body adjusts to the medication. If they persist or become bothersome, inform your doctor. Notify your doctor if you develop breathing difficulties, heart pounding, irregular heartbeat, ringing in the ears, or difficulty urinating while taking this medication. Change from a seated or lying position slowly to avoid dizziness. Use caution in performing activities requiring alertness. Do not use alcohol or other sedating medications to avoid excessive drowsiness.

Drug Interactions

• Azatadine+propoxyphene- Using propoxyphene together with azatadine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.

• Azatadine+potassium- Talk to your doctor before using potassium oral tablets or capsules together with azatadine. Depending on the dose of azatadine and your overall physical health, combining these medications may increase the irritant effects of potassium on your stomach and upper intestine.

• Azatadine+sodium oxybate- Using sodium oxybate together with azatadine may increase side effects such as drowsiness, dizziness, light-headedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination.

• Azatadine+topiramate- Topiramate can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like azatadine. Heat stroke and hospitalization may occur in some people, especially in warm weather and during vigorous exercise. Children are particularly susceptible.

Mechanism of action

Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effectors cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.

Pregnancy Category : B