Details

Thiotepa is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Thiotepa is used to treat cancer of the breast, ovary, bladder, and others. To make sure thiotepa is safe for you tell your doctor if you have liver or kidney disease heart disease or lung problems. Using thiotepa may increase your risk of developing other types of cancer, such as leukaemia. Do not use thiotepa if you are pregnant. It could harm the unborn baby. Use birth control to prevent pregnancy while you are receiving thiotepa, whether you are a man or a woman. Thiotepa use by either parent may cause birth defects.

Typical Uses

Thiotepa is used to treat cancer. It works by slowing or stopping the growth of cancer cells. Thiotepa is often given into the bladder to treat bladder cancer.

Side Effects

Common thiotepa side effects may include skin lesions pain or burning when you urinate, blood in your urine little or no urinating easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin signs of infection-fever, flu symptoms, mouth and throat ulcers, rapid heart rate, rapid and shallow breathing, fainting low red blood cells (anaemia)-pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating or liver problems-nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes).

Drug Interactions

• Thiotepa+adalimumab- Using adalimumab together with thiotepa may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.
• Thiotepa+clozapine- Using clozapine together with thiotepa is not recommended. Clozapine can lower white blood cell count, and combining it with other medications that can also affect bone marrow function such as thiotepa may increase the risk. You may be more likely to develop serious and potentially life-threatening infections as a result.
• Thiotepa+deferiprone- Deferiprone can lower white blood cell count, and combining it with other medications that can also affect bone marrow function such as thiotepa may increase the risk. You may be more likely to develop serious and potentially life-threatening infections as a result.
• Thiotepa+leflunomide- Using leflunomide together with thiotepa may increase the risk of serious infections. Because leflunomide can stay in your blood for a prolonged period after the last dose, interactions with other drugs may occur for some time even after you have stopped taking it.

Mechanism of action

Thiotepa is a chemotherapy agent, prescribed for ovary or breast cancer. It works by killing cancer cells.

Pregnancy Category : D