Details

Orphenadrine is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Orphenadrine is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Do not take this medication if you are allergic to orphenadrine, or if you have problems with urination, an enlarged prostate, glaucoma, a blockage in your stomach or intestines, trouble swallowing, or myasthenia gravis. Before taking orphenadrine, tell your doctor if you are allergic to any drugs, or if you have heart disease a heart rhythm disorder or coronary artery disease.

Typical Uses

Orphenadrine is used to treat muscle spasms/pain. It is usually used along with rest, physical therapy, and other treatment.

Side Effects

Stop using orphenadrine and inform your doctor immediately if you have fast, pounding, or uneven heartbeats confusion, anxiety, agitation, tremors, hallucinations seizure (convulsions) or urinating less than usual or not at all.

Drug Interactions

• Orphenadrine+propoxyphene- Using propoxyphene together with orphenadrine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should take propoxyphene exactly as prescribed by your doctor. Do not take larger doses or use the drug more frequently than prescribed.
• Orphenadrine+buprenorphine- Using buprenorphine together with other medications that cause central nervous system depression such as orphenadrine can lead to serious side effects such as respiratory distress, coma, or even death. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
• Orphenadrine+topiramate- Topiramate can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like orphenadrine. Heat stroke and hospitalization may occur in some people, especially in warm weather and during vigorous exercise. Children are particularly susceptible.
• Orphenadrine+zonisamide- Zonisamide can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like orphenadrine. Heat stroke and hospitalization may occur in some people, especially in warm weather and during vigorous exercise. Children are particularly susceptible.

Mechanism of action

Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect.

Pregnancy Category : C