Details

Norfloxacin is an antibiotic in a group of drugs called fluoroquinolones. Norfloxacin fights bacteria in the body. Norfloxacin is used to treat different bacterial infections of the prostate or urinary tract (bladder and kidneys). Norfloxacin is also used to treat gonorrhoea. You should not use this medication if you have ever had swelling or tearing of a tendon caused by taking norfloxacin or similar antibiotics. You may not be able to use norfloxacin if you have a muscle disorder. Tell your doctor if you have a history of myasthenia gravis. Norfloxacin may cause swelling or tearing of a tendon (the fibre that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. This effect may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant.

Typical Uses

Norfloxacin is used to treat a variety of bacterial infections. This medication belongs to a class of drugs called quinolone antibiotics. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for virus infections (e.g., common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

Side Effects

Norfloxacin can also have serious effects on your nerves, and may cause permanent nerve damage. Common norfloxacin side effects may include headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats dark urine, clay-coloured stools, jaundice (yellowing of the skin or eyes) muscle weakness or trouble breathing diarrhoea that is watery or bloody sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, easy bruising or bleeding depression, confusion, hallucinations, paranoia, tremors, feeling restless or anxious, unusual thoughts or behaviour, insomnia, nightmares seizure (convulsions) or increased pressure inside the skull- severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.

Drug Interactions

• Norfloxacin+tramadol- Tramadol may rarely cause seizures, and combining it with other medications that can also cause seizures such as norfloxacin may increase that risk. The interaction may be more likely if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumour or head trauma.
• Norfloxacin+bedaquiline- Using bedaquiline together with norfloxacin can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances.
• Norfloxacin+ceritinib- Using ceritinib together with norfloxacin can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances.
• Norfloxacin+fingolimod- Before starting fingolimod, let your doctor know if you are currently receiving treatment with norfloxacin. Using fingolimod in this situation can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. This is most likely to occur early on after you start treatment with fingolimod, especially within the first 20 hours after the first dose.

Mechanism of action

Norfloxacin belongs to class of drugs called flouroquinolone antibiotics. Norfloxacin inhibits bacterial reproduction by inhibiting DNA formation, thereby killing the bacteria.

Pregnancy Category : C