Details

Morphine is an opioid pain medication. An opioid is sometimes called a narcotic. Morphine is used to treat moderate to severe pain. Short-acting formulations are taken as needed for pain. Morphine is not for treating short-term pain just after surgery unless you were already taking morphine before the surgery. Misuse of narcotic medicine can cause addiction, overdose, or death, especially in a child or other person using the medicine without a prescription. You should not take this medicine if you have ever had an allergic reaction to morphine or other narcotic medicines, or if you have severe asthma or breathing problems a blockage in your stomach or intestines or a bowel obstruction called paralytic ileus.

Typical Uses

Morphine is used to help relieve moderate to severe pain. Morphine belongs to a class of drugs known as narcotic (opiate) analgesics. It works in the brain to change how your body feels and responds to pain.

Side Effects

Common morphine side effects may include slow heart rate, sighing, weak or shallow breathing chest pain, fast or pounding heartbeats or extreme drowsiness, feeling like you might pass out. Morphine is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.

Drug Interactions

• Morphine+propoxyphene- Using propoxyphene together with morphine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should take propoxyphene exactly as prescribed by your doctor. Do not take larger doses or use the drug more frequently than prescribed.
• Morphine+bupropion- Bupropion may rarely cause seizures, and combining it with other medications that can also cause seizures such as morphine may increase that risk. The interaction may be more likely if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumour or head trauma.
• Morphine+droperidol- Using droperidol together with morphine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances.
• Morphine+naloxone- The following interaction applies only if you are taking naloxone in an injectable formulation. Using morphine together with naloxone can reverse the effects of morphine. If you are a physically dependent patient you may experience withdrawal symptoms. This can cause nausea, vomiting, diarrhoea, aches, fever, runny no

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Mechanism of action

Morphine belongs to class of drugs called opioids. It acts on the brain and nervous system and reduces the responsiveness to pain. Morphine binds and activates the mu, kappa and delta receptors in brain responsible for analgesia (reducing pain).

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