Details

Methylprednisolone is a steroid that prevents the release of substances in the body that cause inflammation. Methylprednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells. Steroid medication, such as methylprednisolone, can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. To make sure methylprednisolone is safe for you, tell your doctor if you have heart disease, high blood pressure kidney or liver disease (especially cirrhosis) a history of tuberculosis a parasite infection (pinworms) glaucoma or cataracts a recent head injury stomach ulcers, ulcerative colitis, or diverticulitis a thyroid disorder low bone mineral density (steroid medication can increase your risk of bone loss) or if you take aspirin on a daily basis or at high doses.

Typical Uses

Methylprednisolone is used to treat conditions such as arthritis, blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/kidney/intestinal/lung diseases, and immune system disorders. It decreases your immune system's response to various diseases to reduce symptoms such as swelling, pain, and allergic-type reactions. This medication is a corticosteroid hormone. Methylprednisolone may also be used with other medications in hormone disorders.

Side Effects

Common methylprednisolone side effects may include blurred vision, tunnel vision, eye pain, or seeing halos around lights shortness of breath (even with mild exertion), swelling, rapid weight gain severe depression, changes in personality, unusual thoughts or behaviour new or unusual pain in an arm or leg or in your back bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds seizure (convulsions) or low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).

Drug Interactions

• Methylprednisolone+adalimumab- Using adalimumab together with methylprednisolone may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.
• Methylprednisolone+bupropion- Bupropion may rarely cause seizures, and combining it with other medications that can also cause seizures such as methylprednisolone may increase that risk. The interaction may be more likely if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumour or head trauma.
• Methylprednisolone+deferasirox- Using deferasirox together with methylprednisolone may increase the risk of gastrointestinal ulcers and bleeding. Talk to your doctor if you have any questions or concerns.
• Methylprednisolone+leflunomide- Using leflunomide together with methylprednisolone may increase the risk of serious infections. Because leflunomide can stay in your blood for a prolonged period after the last dose, interactions with other drugs may occur for some time even after you have stopped taking it.

Mechanism of action

Methylprednisolone belongs to a group of medicines called as corticosteroids. It increases the level of corticosteroid, which are naturally present in the body and thereby controls inflammation. It has anti-inflammatory, metabolic, immune, and hormonal effects on the body.

Pregnancy Category : C