Details

Ifosfamide is a cancer medication that interferes with the growth and spread of cancer cells in the body. Ifosfamide is used with other cancer medicines to treat testicular cancer. Ifosfamide can harm your kidneys as well as affect your nervous system. You should not use ifosfamide if you are allergic to it, or if you have a medical condition that causes urination problems (such as an enlarged prostate). To make sure ifosfamide is safe for you, tell your doctor if you have kidney disease heart disease a recent or active bladder infection if you have ever been treated with busulfan or if your bladder has ever been treated with radiation treatment. Although ifosfamide is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy. Also, do not breastfeed while taking ifosfamide.

Typical Uses

Ifosfamide is used to treat various cancers (such as testicular cancer). It works by slowing or stopping the growth of cancer cells. This drug may also be used to treat other types of cancer (such as sarcomas, lung cancer).

Side Effects

Stop using ifosfamide and inform your doctor if you have sudden weakness or ill feeling, fever, chills, sore throat, cold or flu symptoms painful mouth sores, pain when swallowing, red or swollen gums pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum) or feeling light-headed or short of breath, chest discomfort, wheezing, dry cough or hack, rapid weight loss.

Drug Interactions

• Ifosfamide+adalimumab- Using adalimumab together with ifosfamide may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.
• Ifosfamide+certolizumab- Using ifosfamide together with certolizumab may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.
• Ifosfamide+deferiprone- Deferiprone can lower white blood cell count, and combining it with other medications that can also affect bone marrow function such as ifosfamide may increase the risk. You may be more likely to develop serious and potentially life-threatening infections as a result.
• Ifosfamide+fingolimod- Using fingolimod together with ifosfamide may increase the risk of serious infections. Because fingolimod can stay in your blood for a prolonged period after the last dose, interactions with other drugs may occur for some time even after you have stopped taking it.
• Ifosfamide+golimumab- Using ifosfamide together with golimumab may increase the risk of serious and potentially life-threatening infections. Talk to your doctor if you have any questions or concerns.

Mechanism of action

Ifosfamide belongs to group of medicines called alkylating agents. It inhibits the growth of cancer cells (cytotoxic effects) by interfering with structure and function of DNA that lead to cell death and inhibition of tumour growth.

Pregnancy Category : D