Details

Hydroxyprogesterone is a form of progestin, a manmade form of a female hormone called progesterone. Hydroxyprogesterone is used to lower the risk of premature birth in a woman who has already had one premature baby. This medication will not stop premature labour that has already begun. Hydroxyprogesterone is not for use in women who have had more than one pregnancy. You should not use this medication if you are allergic to hydroxyprogesterone or castor oil, or if you have unusual vaginal bleeding, liver disease or liver cancer, breast cancer, uterine cancer, uncontrolled high blood pressure, a history of jaundice caused by pregnancy, or a history of stroke, blood clot, or circulation problems. Before you receive hydroxyprogesterone, tell your doctor if you have eclampsia or preeclampsia, kidney disease, high blood pressure, heart disease, migraine headaches, a personal or family history of diabetes, asthma, seizures, depression, or fluid retention.

Typical Uses

Hydroxyprogesterone is used in women who are pregnant with a single baby, and who have delivered a baby too early (preterm) in the past. It is used to help lower the risk of having a preterm baby again. Hydroxyprogesterone is a man-made form of a female hormone (progestin). It is not known how it works to prevent preterm births. This medication is not intended to prevent preterm birth in women pregnant with more than one baby (such as twins, triplets). It is also not intended to stop active preterm labour. Hydroxyprogesterone is usually started during the 16th week of pregnancy and given once per week until the 37th week or until your baby is born.

Side Effects

Some of the side effects of hydroxyprogesterone include sudden numbness or weakness, especially on one side of the body swelling, oozing, bleeding, or worsening pain where the injection was given sudden severe headache, confusion, problems with vision, speech, or balance pain, swelling, warmth, or redness in one or both legs jaundice (yellowing of the skin or eyes) swelling in your hands, ankles, or feet or symptoms of depression (sleep problems, weakness, mood changes).

Drug Interactions

• Hydroxyprogesterone+acarbose- Hydroxyprogesterone may interfere with blood glucose control and reduce the effectiveness of acarbose and other diabetic medications. Monitor your blood sugar levels closely. You may need a dose adjustment of your diabetic medications during and after treatment with hydroxyprogesterone.
• Hydroxyprogesterone+acetaminophen- Hydroxyprogesterone may reduce the blood levels and effects of acetaminophen. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
• Hydroxyprogesterone+duloxetine- Hydroxyprogesterone may reduce the blood levels and effects of duloxetine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
• Hydroxyprogesterone+glyburide- Hydroxyprogesterone may interfere with blood glucose control and reduce the effectiveness of glyburide and other diabetic medications. Monitor your blood sugar levels closely. You may need a dose adjustment of your diabetic medications during and after treatment with hydroxyprogesterone.
• Hydroxyprogesterone+letrozole- Hydroxyprogesterone may reduce the blood levels and effects of letrozole. Contact your doctor if your symptoms worsen or your condition changes during treatment with

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Mechanism of action

Hydroxyprogesterone belongs to a class of medications called progestin (female hormones). It is a synthetic form of the female hormone progesterone, however the exact mechanism by which it reduces risk of preterm birth is not known.

Pregnancy Category : B