Details

Goserelin is a man-made form of a hormone that regulates many processes in the body. Goserelin overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. Goserelin implant is used in men to treat symptoms of prostate cancer. Goserelin implant is used in women to treat breast cancer or endometriosis. Goserelin is also used in women to prepare the lining of the uterus for endometrial ablation (a surgery to correct abnormal uterine bleeding). To make sure goserelin is safe for you, tell your doctor if you have diabetes heart disease or prior heart attack a history of heart attack or stroke risk factors for coronary artery disease (such as high blood pressure, high cholesterol, smoking, or being overweight) personal or family history of long QT syndrome osteoporosis or low bone density a condition affecting your spine abnormal vaginal bleeding that has not been checked by a doctor or if you take a blood thinner such as warfarin. Goserelin can decrease bone mineral density, which may increase your risk of developing osteoporosis. Unless you are being treated for advanced breast cancer, you should not use goserelin during pregnancy.

Typical Uses

Goserelin is used in men to treat prostate cancer. It is used in women to treat certain breast cancers or a certain uterus disorder (endometriosis). It is also used in women to thin the lining of the uterus (endometrium) in preparation for a procedure to treat abnormal uterine bleeding. Talk to your doctor about the risks and benefits of treatment. Goserelin is similar to a natural hormone made by the body (luteinizing hormone releasing hormone-LHRH). It works by decreasing testosterone hormones in men and oestrogen hormones in women. This effect helps to slow or stop the growth of certain cancer cells and uterine tissue that need these hormones to grow and spread. This medication may also be used to stop early puberty in children.

Side Effects

Common side effects of goserelin include painful or difficult urination pain, bruising, swelling, redness, oozing, or bleeding where the implant was injected high blood sugar-increased thirst, increased urination, hunger, dry mouth, fruity breath odour, drowsiness, dry skin, blurred vision, weight loss high calcium levels-nausea, vomiting, constipation, increased thirst or urination, muscle pain or weakness, bone pain, confusion, and feeling tired or restless heart attack symptoms-chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating nerve problems-back pain, muscle weakness, problems with balance or coordination, severe numbness or tingling in your legs or feet, loss of bladder or bowel control or signs of a stroke-sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Drug Interactions

• Goserelin+amiodarone- Using amiodarone together with goserelin can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances.
• Goserelin+bedaquiline- Using bedaquiline together with goserelin can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances.
• Goserelin+ceritinib- Using ceritinib together with goserelin can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances.
• Goserelin+fingolimod- Before starting fingolimod, let your doctor know if you are currently receiving treatment with goserelin. Using fingolimod in this situation can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. This is most likely to occur early on after you start treatment with fingolimod, especially within the first 20 hours after the first dose. You may also be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte d

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Mechanism of action

Goserelin is a synthetic hormone belonging to the class of gonadotropin-releasing hormone (GnRH) agonists. It works by reducing the levels of certain hormones (testosterone/oestrogen) in the body and also reduces the size of the noncancerous growth in the uterus.

Pregnancy Category : X